A model regulatory mechanism illustrating the direct molecular route of NLRP3-driven hepatic IR and steatosis (IMAGE) (IMAGE)

Science China Press

A model regulatory mechanism illustrating the direct molecular route of NLRP3-driven hepatic IR and steatosis (IMAGE)

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The transcription factor YY1 promotes NLRP3 expression in response to stimuli, which drives hepatic IR and steatosis by directly interacting with and promoting PKCε membrane translocation.

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©Science China Press

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