Figure. Designed novel fold proteins. (IMAGE) National Institutes of Natural Sciences Caption From the top, the protein name, topology diagram (circles represent α-helices, triangles and arrows represent β-strands), computationally designed structures, and experimentally determined structures. The topology of NF8-01 forms a knot. Credit Shintaro Minami, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Rie Tatsumi-Koga, George Chikenji & Nobuyasu Koga, "Exploration of novel αβ-protein folds through de novo design", Nature Structural & Molecular Biology (2023) Usage Restrictions Credit must be given to the creator. License CC BY Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.