Metformin ameliorates HMGB1-mediated oxidative stress in periodontitis. (IMAGE)
Caption
Periodontitis increase the expression of proinflammatory cytokine HMGB1. HMGB1 affects the expression of inflammation-related cytokines (IL-6, IL-8) and aggravates periodontal tissue destruction and oxidative stress. Metformin activates autophagy through mTOR pathway, regulate the expression, translocation and release of HMGB1, and then reduce the oxidative stress and tissue destruction of periodontal tissue.
Credit
Genes & Diseases
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CC BY-NC-ND