Genomic landscape of schistosomiasis-associated colorectal cancer. (IMAGE)
Caption
Genomic landscape of schistosomiasis-associated colorectal cancer. (A) Genetic characteristics of the SA-CRC. The number of mutations, the tumor mutation burden, the estimated MSI scores, and the predicted number of neo-epitopes of each sample were present. (B) Mutational landscape of recurrently mutated genes in SA-CRCs. Red arrow corresponds to the known driver gene, and the yellow arrow correspond to the novelly predicted driver genes. (C) Landscape of somatic copy number alternations (SCNAs) in SA-CRCs. Heatmap of SCNAs across all the samples (left) and the significant enriched SCNA regions (right) were showed. (D) Recurrently mutated genes with significant differences in frequency between SA-CRC and S-CRC. Gold star denotes the genes highly mutated in SA-CRC. (E–H) Comparison of recurrently mutated genes in frequency between SA-CRC and other types of CRC. Red star denotes the genes showing significant differences in frequency between two datasets. (I) Comparison of known oncogenic signaling pathways in frequency between SA-CRC and S-CRC. (J) Dot plot of the conventional enriched pathways in SA-CRC. The small Venn plot shows the overlap of enriched pathways between SA-CRC and S-CRC.
Credit
Genes & Diseases
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