The many scales of biological variation in the skin that we predict will have a significant effect on transcriptional heterogeneity (IMAGE)

Elsevier

The many scales of biological variation in the skin that we predict will have a significant effect on transcriptional heterogeneity

Caption

(a) The spatial scale represents how skin composition and characteristics vary across anatomical regions. (b) The temporal scale represents changes to skin across the human lifespan. (c) The gender scale represents gender-specific differences between skin sites and function. (d) The ancestral origin scale, which affects skin characteristics and proclivity to disease. (e) The wound response scale, where unwounded skin is distinct from the skin that is permanently altered after the innate, acute wound repair program. For each scale, we include notable examples that illustrate why these factors need to be considered when generating a high-quality single-cell skin atlas.

Credit

Journal of Investigative Dermatology

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License

CC BY-NC-ND

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