Graphical summary (IMAGE) PNAS Nexus Caption Depletion of peripheral Foxp3-expressing cells leads to elevated levels of monocytes and granulocytes, causing disruption of blood-brain barrier, triggering the activation of inflammasome in the brain. Credit Pasinetti et al. Usage Restrictions None License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.