(IMAGE)
Caption
An infographic depicting a unique “natural senolytic” or natural senescent cell removal mechanism identified by Japanese researchers, in naked mole-rats, the longest-lived rodent species. They proposed a species-specific mechanism involving activation of INK4a-RB-signaling and serotonin metabolism, which increases intracellular oxidative damage, and causes subsequent death of senescent NMR cells.
Credit
Yoshimi Kawamura and Kyoko Miura from Kumamoto University, Japan
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