m6A mRNA修饰能够调控Th17细胞亚群的功能 (IMAGE)

Science China Press

m6A mRNA修饰能够调控Th17细胞亚群的功能

Caption

Th17细胞中METTL3的缺失促进了SOCS家族RNA的稳定性，抑制了IL-6/STAT3介导的IL-17A和CCR5的表达，从而阻碍了Th17细胞的分化和浸润，最终减弱了EAE的过程。

Credit

©《中国科学》杂志社

Usage Restrictions

Use with credit.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.