LINC00901 regulates MYC signaling pathway. (IMAGE)
Caption
LINC00901 regulates MYC signaling pathway. (A) LINC00901 level is significantly associated with MAPK signaling pathway. Bulb map of KEGG pathway analysis of differentially expressed genes in MIA PaCa-2 LINC00901 overexpression or KO cells compared with vector control cells. X-axis represented the ratio of enriched differential genes in each pathway. Y-axis indicated names of statistics of pathway enrichment. The area of each node represented the number of enriched differential genes. The p-values were indicated by different color changes from blue to red. (B) GSEA analysis indicates that LINC00901 is involved in MAPK signaling. NES, normalized enrichment score. (C) Association between the enrichment of MYC targets and LINC00901 expression by GSEA analysis. (D, E) The expression of MYC regulated genes related to cell cycle and EMT in LINC00901 overexpression (D) or KO cells (E) was detected by qRT-PCR. Values are mean ± S.D., n = 3; ∗∗P < 0.01.
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Genes & Diseases
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